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Issue 7, 2015
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2D protein arrays induce 3D in vivo-like assemblies of cells

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Abstract

We report on the ability of two-dimensional protein crystals to induce the formation of homo- and heterotypic multicellular spheroids (MCSs) which resemble the morphology and hierarchical organization of living tissues and tumours. We have systematically studied the influence of the initial cell density and incubation time on the kinetics of spheroid growth and spheroid lifespan. Hereby a novel methodology has been established to produce MCSs on protein-based molecular layers.

Graphical abstract: 2D protein arrays induce 3D in vivo-like assemblies of cells

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Publication details

The article was received on 16 Oct 2014, accepted on 07 Jan 2015 and first published on 16 Jan 2015


Article type: Communication
DOI: 10.1039/C4SM02278E
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Soft Matter, 2015,11, 1259-1264

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    2D protein arrays induce 3D in vivo-like assemblies of cells

    S. Moreno-Flores and S. Küpcü, Soft Matter, 2015, 11, 1259
    DOI: 10.1039/C4SM02278E

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