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Issue 41, 2012
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A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation

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Abstract

A new microfluidic setup with impact-jet micromixers was built up and applied to control the nanoprecipitation process for generating polymeric nanoparticles and encapsulating a lipophilic drug. In contrast to a conventional nanoprecipitation processes in “bulk” phase, the microfluidic approach not only allows a continuous and controlled production of nanoparticles, but can also be used to manipulate and modify the nanoparticle size and the drug loading, by fine tuning the processing parameters. We developed a micromixer-assisted setup that can efficiently produce PMMA nanospheres, with a particle size of about 100 nm, and a narrow size distribution. Moreover, this setup enables a flow rate of the polymer phase as high as 1 mL min−1, opening the possibilities of large-scale production. The obtained nanoparticles can encapsulate high levels of a lipophilic drug (ketoprofen) and release it over 4 h. Finally, the solvent and non-solvent flow rates can be used to adjust the physicochemical and encapsulating/release properties of these nanosystems, opening new possibilities for nanoparticle production by nanoprecipitation.

Graphical abstract: A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation

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Supplementary files

Article information


Submitted
17 Feb 2012
Accepted
05 Apr 2012
First published
08 May 2012

Soft Matter, 2012,8, 10628-10635
Article type
Paper

A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation

N. Anton, F. Bally, C. A. Serra, A. Ali, Y. Arntz, Y. Mely, M. Zhao, E. Marchioni, A. Jakhmola and T. F. Vandamme, Soft Matter, 2012, 8, 10628
DOI: 10.1039/C2SM25357G

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