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Issue 41, 2012
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Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

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Abstract

We use a perfluorinated-dendrimer–dye complex that stabilizes microbubbles as a novel pore-forming agent. We use microfluidics to produce monodisperse emulsions containing a polymer matrix material, a model active, and the perfluorinated complex; upon drying, the emulsions form porous microspheres. This porosity causes the encapsulated model active to be released faster than from non-porous microspheres. Moreover, because of the fluorous features of the pores, we can also attach an additional guest molecule to the pores which is released with a profile that is distinct from that of the encapsulated active. These porous microspheres can encapsulate and controllably release multiple actives; this makes them valuable for applications such as drug delivery and imaging.

Graphical abstract: Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

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Article information


Submitted
25 Mar 2012
Accepted
30 Apr 2012
First published
14 May 2012

Soft Matter, 2012,8, 10636-10640
Article type
Paper

Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

W. J. Duncanson, M. Zieringer, O. Wagner, J. N. Wilking, A. Abbaspourrad, R. Haag and D. A. Weitz, Soft Matter, 2012, 8, 10636
DOI: 10.1039/C2SM25694K

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