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Issue 5, 2012
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Controlled hydrogel photopolymerization inside live systems by X-ray irradiation

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Abstract

We successfully demonstrate the in situ formation by X-ray irradiation induced polymerization of a three-dimensional (3D) hydrogel based on poly(ethylene glycol) (PEG) diacrylate (PEG DA), with the option of heparin incorporation to enhance cell adhesion. The polymerization reaction can be completed in tens of seconds, thanks to the fast and uniform X-ray induced process. Eliminating polymerization initiators and the residual unreacted monomers improves the biocompatibility and stability of the hydrogel. The photopolymerization mechanism can be locally controlled by using a trimmed or a focused X-ray beam to allow precise in vivo administration deep in the tissue, without surgery. We also demonstrate that photopolymerized hydrogels containing polyethylenimine (PEI)/nucleic acid (DNA or small interfering RNA, siRNA) nanoparticles (NPs) can deliver such nanoparticles. The hydrogel is biocompatible with mice and is not toxic to epithelial cells.

Graphical abstract: Controlled hydrogel photopolymerization inside live systems by X-ray irradiation

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Supplementary files

Article information


Submitted
06 Sep 2011
Accepted
09 Nov 2011
First published
02 Dec 2011

Soft Matter, 2012,8, 1420-1427
Article type
Paper

Controlled hydrogel photopolymerization inside live systems by X-ray irradiation

S.-Ja Tseng, C. Chien, Z. Liao, H. Chen, Y. Kang, C. Wang, Y. Hwu and G. Margaritondo, Soft Matter, 2012, 8, 1420
DOI: 10.1039/C1SM06682J

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