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Issue 6, 2019
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Ni-catalysed reductive arylalkylation of unactivated alkenes

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Abstract

In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggest a reaction pathway with an intermediate reduction.

Graphical abstract: Ni-catalysed reductive arylalkylation of unactivated alkenes

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Publication details

The article was received on 26 Sep 2018, accepted on 03 Dec 2018 and first published on 04 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC04279A
Chem. Sci., 2019,10, 1780-1785
  • Open access: Creative Commons BY-NC license
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    Ni-catalysed reductive arylalkylation of unactivated alkenes

    Y. Jin and C. Wang, Chem. Sci., 2019, 10, 1780
    DOI: 10.1039/C8SC04279A

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