Issue 30, 2020, Issue in Progress

One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups

Abstract

One-pot oxime ligation under mild conditions using Pd(II) as a shared catalyst from an aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two complementary metal-free protocols using unmasked Aoa-peptide are also described. Acetoxime-peptide can proceed to the desired oxime through an additional transoximation step.

Graphical abstract: One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2020
Accepted
17 Apr 2020
First published
06 May 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 17681-17685

One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups

S. Duflocq, J. Zhou, F. Huguenot, M. Vidal and W. Liu, RSC Adv., 2020, 10, 17681 DOI: 10.1039/D0RA03235B

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