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Issue 77, 2017
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Towards the development of multifunctional hybrid fibrillary gels: production and optimization by colloidal electrospinning

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Abstract

The incorporation of thermosensitive microgels that can act as active sites into polymeric fibers through colloidal electrospinning originates multifunctional, highly porous, and biocompatible membranes suitable for biomedical applications. The use of polyvinylpyrrolidone (PVP), a biocompatible, water-soluble polymer as a fiber template, not only allows the use of a simple set-up to produce composite membranes, but also avoids the use of organic solvents to prepare such systems. Further crosslinking with ultraviolet (UV) radiation avoids membrane dissolution in physiological conditions. Highly porous, UV crosslinked composite membranes with monodisperse mean fiber diameters around 530 nm were successfully produced. These composite membranes showed a Young Modulus of 22 MPa, and an ultimate tensile strength of 3 MPa, accessed in the mechanical tests. Furthermore, the same composite membranes were able to swell about 30 times their weight after 1 hour in aqueous medium. In this work composite multifunctional membranes were designed and extensively studied. PVP, a biocompatible water-soluble polymer, was used as a fiber template to incorporate thermoresponsive poly-(N-isopropylacrylamide) (PNIPAAm)-based microgels into the composite membrane using colloidal electrospinning. The design of multifunctional membranes can be further tailored to several biomedical applications such as temperature-controlled drug delivery systems.

Graphical abstract: Towards the development of multifunctional hybrid fibrillary gels: production and optimization by colloidal electrospinning

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Publication details

The article was received on 28 Jun 2017, accepted on 12 Oct 2017 and first published on 17 Oct 2017


Article type: Paper
DOI: 10.1039/C7RA07166C
Citation: RSC Adv., 2017,7, 48972-48979
  • Open access: Creative Commons BY license
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    Towards the development of multifunctional hybrid fibrillary gels: production and optimization by colloidal electrospinning

    J. Faria, C. Echeverria, J. P. Borges, M. H. Godinho and P. I. P. Soares, RSC Adv., 2017, 7, 48972
    DOI: 10.1039/C7RA07166C

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