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Issue 94, 2015
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Penchinones A–D, two pairs of cis-trans isomers with rearranged neolignane carbon skeletons from Penthorum chinense

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Abstract

Penchinones A–D (1–4), two pairs of novel cis-trans lignan isomers with rearranged neolignane carbon skeletons, together with six known flavonoids (5–10), were isolated from the ethyl acetate-soluble portion of a hepatoprotective water decoction of Penthorum chinense. Their structures were determined by extensive spectroscopic data analysis, ECD calculation, and single-crystal X-ray diffraction. Penchinones C and D (3 and 4) featured an unprecedented 7,3′-neolignane carbon skeleton. Penchinone A (1) exhibited protective activity against acetaminophen-induced damage to the HL7702 hepatocyte and selective cytotoxicity against the human cancer ovarian cell line, Hey, in vitro.

Graphical abstract: Penchinones A–D, two pairs of cis-trans isomers with rearranged neolignane carbon skeletons from Penthorum chinense

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Supplementary files

Article information


Submitted
09 Aug 2015
Accepted
04 Sep 2015
First published
04 Sep 2015

RSC Adv., 2015,5, 76788-76794
Article type
Paper
Author version available

Penchinones A–D, two pairs of cis-trans isomers with rearranged neolignane carbon skeletons from Penthorum chinense

Y. He, C. Peng, X. Xie, M. Chen, X. Li, M. Li, Q. Zhou, L. Guo and L. Xiong, RSC Adv., 2015, 5, 76788 DOI: 10.1039/C5RA15982B

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