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Issue 86, 2015
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Facile synthesis of size and wavelength tunable hollow gold nanostructures for the development of a LSPR based label-free fiber-optic biosensor

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Abstract

Hollow bimetallic nanostructures have recently emerged as attractive plasmonic materials due to the ease of optical tunability by changing their size/composition. Currently available methods, in addition to being tedious and time-consuming, result in polydispersed nanostructures, particularly due to polydispersed templates. In this study, optically tunable hollow gold nanostructures (HGNS) were synthesized by galvanic replacement reaction between silver nanospheres (AgNS) templates and gold salt. Monodispersed AgNS were created using a gold seed-mediated heteroepitaxial growth. Since it is easier to ensure monodispersed gold nanosphere seeds, the resulting AgNS showed a tight control on size. Hollow gold nanostructures 43–70 nm in size with extinction maxima ranging between 450–590 nm were produced by varying the gold to silver molar ratio. The nanostructures were observed to be monodispersed and uniform (SD ≤ 11%) in all the batches. Furthermore, the synthesized HGNS were immobilized on dendrimer-functionalized U-shaped fiber-optic probes to develop a localized surface plasmon resonance (LSPR) based sensor. Refractive index sensitivity of the HGNS based sensors was found to be 1.5-fold higher than solid gold nanosphere (GNS)-based fiber-optic sensors. These HGNS-based fiber-optic probes were subsequently used to develop an immunosensor with improved sensitivity by using human immunoglobulin-G (HIgG) as receptor molecules and goat-anti-HIgG as a target analyte.

Graphical abstract: Facile synthesis of size and wavelength tunable hollow gold nanostructures for the development of a LSPR based label-free fiber-optic biosensor

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Supplementary files

Article information


Submitted
15 Jul 2015
Accepted
10 Aug 2015
First published
11 Aug 2015

RSC Adv., 2015,5, 69970-69979
Article type
Paper
Author version available

Facile synthesis of size and wavelength tunable hollow gold nanostructures for the development of a LSPR based label-free fiber-optic biosensor

J. Satija, J. Tharion and S. Mukherji, RSC Adv., 2015, 5, 69970
DOI: 10.1039/C5RA13941D

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