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Issue 88, 2015
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A near-infrared chemodosimeter with Pi-selective colorimetric and fluorescent sensing and its application in vivo imaging

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Abstract

A near-infrared colorimetric and fluorescent chemosensor for detecting phosphate ion (Pi) has been developed. The chemosensor's sensing mechanism is based on the Pi-driven cleavage of an amide bond which releases a fluorophore. The chemosensor exhibits a rapid response and high sensitivity towards Pi in DMSO–HEPES buffer (0.02 M, pH = 7.0) (v/v = 9 : 1). A colorimetric change with a 70 nm red-shift in the UV-vis absorbance spectrum and a 72-fold enhancement in the ratio of fluorescence intensities at 656 nm and 552 nm were observed. The practical utility of this chemosensor was demonstrated by employing it to detect Pi in Paramecium and C. elegans.

Graphical abstract: A near-infrared chemodosimeter with Pi-selective colorimetric and fluorescent sensing and its application in vivo imaging

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Supplementary files

Article information


Submitted
02 Jul 2015
Accepted
07 Aug 2015
First published
10 Aug 2015

RSC Adv., 2015,5, 71756-71759
Article type
Communication
Author version available

A near-infrared chemodosimeter with Pi-selective colorimetric and fluorescent sensing and its application in vivo imaging

T. N. Zang, R. R. Zhao, X. Z. Yang, Y. Gao, G. K. Wang, Y. Zhou, B. Liu and J. F. Zhang, RSC Adv., 2015, 5, 71756
DOI: 10.1039/C5RA12835H

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