A novel electrocatalyst with high sensitivity in detecting glutathione reduced by 2-hydroxypropyl-β-cyclodextrin enveloped 10-methylphenothiazine

Abstract

This paper reports on an experimental research of a 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) enveloped 10-methylphenothiazine (MPT) catalyst (MPT-HP-β-CD) with high sensitivity and wonderful electrical conductivity for the electrochemical detection of reduced glutathione (GSH) in a neutral environment. We obtained a linear response range from 10⁻⁶ mol L⁻¹ to 5.8 × 10⁻⁴ mol L⁻¹ for GSH with a low detection limit of 2.87 × 10⁻⁷ mol L⁻¹, providing a potentially usefulness in the development of sensors for non-enzyme detection of GSH.