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Issue 20, 2013
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Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases

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Abstract

The formation of a tri-base pairing from free nucleobases is rare. A co-crystal structure obtained from an equimolar mixture of 6-isopropyluracil and adenine shows the formation of a tri-base pairing, where one molecule of free adenine is adhered to two molecules of the free pyrimidine nucleobase, involving both Watson–Crick and Hoogsteen base-pairing interactions.

Graphical abstract: Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases

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Article information


Submitted
13 Feb 2013
Accepted
20 Mar 2013
First published
21 Mar 2013

RSC Adv., 2013,3, 7282-7284
Article type
Communication

Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases

K. Radhakrishnan, L. N. Burgula and L. M. Kundu, RSC Adv., 2013, 3, 7282
DOI: 10.1039/C3RA40766G

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