Promising reagents for difluoroalkylation
This review describes recent advances in difluoroalkylation reactions using different substrates. Generally speaking, RCF2 radical is generally proposed in the mechanism of these reactions. At present, the most used difluoroalkylation reagent is RCF2X, which can be reduced by metal, photocatalyst or bases to RCF2 radical. Various substrates such as alkenes, alkynes, amines and so on could well be applied to these difluoroalkylation reactions.
- This article is part of the themed collection: 2020 Organic Chemistry Frontiers Review-type Articles