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Issue 17, 2020

Promising reagents for difluoroalkylation

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Abstract

This review describes recent advances in difluoroalkylation reactions using different substrates. Generally speaking, RCF2 radical is generally proposed in the mechanism of these reactions. At present, the most used difluoroalkylation reagent is RCF2X, which can be reduced by metal, photocatalyst or bases to RCF2 radical. Various substrates such as alkenes, alkynes, amines and so on could well be applied to these difluoroalkylation reactions.

Graphical abstract: Promising reagents for difluoroalkylation

Article information


Submitted
11 May 2020
Accepted
06 Jul 2020
First published
06 Jul 2020

Org. Chem. Front., 2020,7, 2538-2575
Article type
Review Article

Promising reagents for difluoroalkylation

D. Dong, H. Yang, J. Shi, W. Si, Z. Wang and X. Xu, Org. Chem. Front., 2020, 7, 2538 DOI: 10.1039/D0QO00567C

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