Jump to main content
Jump to site search

Issue 9, 2018
Previous Article Next Article

Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

Author affiliations

Abstract

A facile synthetic method to access 4-amino-isoquinolin-1(2H)-one and oxazole derivatives was disclosed in this paper. The reaction of N-(pivaloyloxy)-amides with ynamides produced 4-amino-isoquinolin-1(2H)-ones in good yields in the presence of Cp*Rh(III) catalyst through a C–H bond functionalization. Using Sc(OTf)3 as the catalyst, oxazole derivatives were obtained in good yields from the same reaction. This protocol features good functional group tolerance and excellent regioselectivity.

Graphical abstract: Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

Back to tab navigation

Supplementary files

Article information


Submitted
03 Feb 2018
Accepted
05 Mar 2018
First published
08 Mar 2018

Org. Chem. Front., 2018,5, 1466-1470
Article type
Research Article

Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

B. Niu, R. Liu, Y. Wei and M. Shi, Org. Chem. Front., 2018, 5, 1466
DOI: 10.1039/C8QO00125A

Social activity

Search articles by author

Spotlight

Advertisements