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Issue 10, 2016
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Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

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Abstract

An efficient and highly regioselective protocol for copper(II)-catalyzed remote C–H fluoroalkylation of 8-aminoquinoline amides with RfSO2Na (Rf = CF3, CF2H, C4F9, C5F11, and C6F13) is described. This reaction provides an effective strategy for the direct construction of fluorine-containing six-membered heteroaromatic core structures.

Graphical abstract: Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

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Supplementary files

Article information


Submitted
19 Jul 2016
Accepted
12 Aug 2016
First published
12 Aug 2016

Org. Chem. Front., 2016,3, 1309-1313
Article type
Research Article

Copper-catalyzed 8-amido chelation-induced regioselective C–H fluoroalkylation of quinolines

L. Jin, G. Lu and C. Cai, Org. Chem. Front., 2016, 3, 1309 DOI: 10.1039/C6QO00369A

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