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Issue 24, 2015
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Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

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Abstract

Electroconductive hydrogels are composed of 3-dimensionally structured hydrogels and conducting molecules with electrical, optical, and reversible redox properties. These hybrid materials can be utilized as electrically-stimulated biomaterials in implantable biosensors or drug delivery systems. In this study, carbon nanotube-incorporated polyvinyl alcohol (PVA)-based hydrogels were synthesized by an electro-click reaction, which was controlled by an electrochemically generated Cu(I) catalyst. When the reduction potential of Cu(II) ions was applied, PVA-based hydrogels were deposited onto indium-tin-oxide-coated glass electrodes via Cu(I)-catalysed alkyne–azide cycloaddition (click reaction). When the hydrogels contained carbon nanotubes, thicker films were deposited because the embedded carbon nanotubes provided a larger electrochemical active area. In addition, the carbon nanotubes improved the electrical conductivity of the hydrogel systems. We investigated the electro-stimulated drug release behaviour with electro-click conductive hydrogels using tetracycline as a model drug.

Graphical abstract: Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

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Supplementary files

Article information


Submitted
13 Apr 2015
Accepted
13 May 2015
First published
13 May 2015

Polym. Chem., 2015,6, 4473-4478
Article type
Paper
Author version available

Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

E. J. Choi, J. Shin, Z. H. Khaleel, I. Cha, S. Yun, S. Cho and C. Song, Polym. Chem., 2015, 6, 4473
DOI: 10.1039/C5PY00545K

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