SCHEDULED MAINTENANCE
Construction of the estrane ring system was achieved by the Intramolecular double Michael reaction as the key step. Heating of the α,β-unsaturated enone ester (18), prepared from the optically active indanone (4), with chlorotrimethylsilane, triethylamine, and zinc chloride produced three estrane derivatives (19), (22), and (25).
M. Ihara, T. Takahashi, N. Shimizu, Y. Ishida, I. Sudow, K. Fukumoto and T. Kametani, J. Chem. Soc., Perkin Trans. 1, 1989, 529 DOI: 10.1039/P19890000529
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