Applications of substituted arylacetaldehydes in the total synthesis of seco-mesembrane alkaloids. Part 1. The total synthesis of (±)-O-methyljoubertiamine
Abstract
The substituted arylacetaldehyde 2-(p-methoxyphenyl)-5-dimethylaminobutanol (1a) is shown to serve as a precursor in the total synthesis of the seco-mesembrane alkaloid (±)-O-methyljoubertiamine (2; R1R2= O, R3= Me, Δ7 unsaturation).