Studies on lysergic acid diethylamide and related compounds. Part 8. Structural identification of new metabolites of lysergic acid diethylamide obtained by microbial transformation using Streptomyces roseochromogenes
Microbial transformation of lysergic acid diethylamide (1) by Streptomyces roseochromogenes gave a known product, lysergic acid ethylamide (5), and two new ones. The structures of these new metabolites have been chemically established as lysergic acid ethylvinylamide (7) and lysergic acid ethyl-2-hydroxyethylamide (8).