Calciferol and its relatives. Part 26. A conversion of cholesterol into 8-hydroxymethyl-des-AB-cholest-8-ene
Abstract
The methoxy-ketone (7), derived from Westphalen's diol, was degraded to 8α-benzoyloxymethyl-des-AB-cholestan-9-one (10), from which the title compound (6) was obtained in a yield of 47% based on the ketone (7), or 22.5% overall from cholesterol. The allylic alcohol (6) thus becomes relatively easily accessible.