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Issue 32, 2019
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Copper(i)-catalyzed benzylation of triazolopyridine through direct C–H functionalization

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Abstract

A general and efficient copper-catalyzed benzylation reaction of triazolopyridine with N-tosylhydrazones was developed. This reaction forms a C(sp2)–C(sp3) bond through cross-coupling, and represents an exceedingly practical method to afford 3-benzylated triazolopyridines in moderate to good yields. A proposed mechanistic pathway underlying this reaction was outlined. This catalytic transformation should enable broad synthetic applications in functionalization chemistry, allowing the synthesis of new pharmaceutically relevant triazolopyridine derivatives.

Graphical abstract: Copper(i)-catalyzed benzylation of triazolopyridine through direct C–H functionalization

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Supplementary files

Article information


Submitted
26 Jun 2019
Accepted
24 Jul 2019
First published
24 Jul 2019

Org. Biomol. Chem., 2019,17, 7455-7460
Article type
Paper

Copper(I)-catalyzed benzylation of triazolopyridine through direct C–H functionalization

M. Reddy Lonka, J. Zhang, T. Gogula and H. Zou, Org. Biomol. Chem., 2019, 17, 7455
DOI: 10.1039/C9OB01433K

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