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Issue 44, 2018
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Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

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Abstract

A novel transition metal-free decarboxylative fluoroalkylation of activated alkenes and C–H functionalization cascade process has been developed. This approach provides an efficient way to construct valuable 1,1-dimethyl-2,2,2-trifluoroethyl substituted oxindoles.

Graphical abstract: Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

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Publication details

The article was received on 02 Oct 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02457J
Citation: Org. Biomol. Chem., 2018,16, 8472-8476

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    Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

    Y. Shi, H. Xiao, X. Xu and Y. Huang, Org. Biomol. Chem., 2018, 16, 8472
    DOI: 10.1039/C8OB02457J

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