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Issue 33, 2018
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A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

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Abstract

Ruthenium catalyzed oxidative alkenylation of N-aryl pyridazinediones and N-aryl phthalazinediones with acrylates and subsequent intramolecular cyclization of the resulting product in water as a green solvent were accomplished. Diverse derivatives of pyridazino[1,2-a]indazoles and indazolo[1,2-b]phthalazines were readily prepared in moderate to high yields by this methodology from easily accessible starting materials via cascade directed C–H bond activation/annulation reactions.

Graphical abstract: A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

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Supplementary files

Article information


Submitted
28 Apr 2018
Accepted
23 Jul 2018
First published
03 Aug 2018

Org. Biomol. Chem., 2018,16, 5973-5978
Article type
Paper

A ruthenium-catalyzed alkenylation–annulation approach for the synthesis of indazole derivatives via C–H bond activation

M. Gholamhosseyni and E. Kianmehr, Org. Biomol. Chem., 2018, 16, 5973
DOI: 10.1039/C8OB00999F

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