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Issue 33, 2018
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Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

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Abstract

Catalytic alkylation reactions of weakly acidic carbonyl and related pronucleophiles such as amides, esters, and sulfonamides with substituted alkenes have been reported. In the presence of a strong Brønsted base catalyst system, potassium hexamethyldisilazide and 18-crown-6 ether, the desired reactions proceeded in high yields at ambient temperature with a wide substrate scope. These are atom-economical catalytic alkylation reactions of carbonyl and related compounds.

Graphical abstract: Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

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Article information


Submitted
21 Apr 2018
Accepted
08 Jun 2018
First published
08 Jun 2018

Org. Biomol. Chem., 2018,16, 5969-5972
Article type
Paper
Author version available

Catalytic alkylation reactions of weakly acidic carbonyl and related compounds using alkenes as electrophiles

Y. Yamashita, R. Igarashi, H. Suzuki and S. Kobayashi, Org. Biomol. Chem., 2018, 16, 5969
DOI: 10.1039/C8OB00941D

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