Issue 11, 2017

An efficient Sn(ii)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework

Abstract

A novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C–N cyclization reaction.

Graphical abstract: An efficient Sn(ii)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework

Supplementary files

Article information

Article type
Paper
Submitted
07 Feb 2017
Accepted
21 Feb 2017
First published
21 Feb 2017

Org. Biomol. Chem., 2017,15, 2385-2391

An efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework

S. S. Chavan, M. V. Supekar, P. A. Burate, B. D. Rupanwar, A. M. Shelke and G. Suryavanshi, Org. Biomol. Chem., 2017, 15, 2385 DOI: 10.1039/C7OB00294G

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