Jump to main content
Jump to site search

Issue 3, 2017
Previous Article Next Article

Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp2)–O cross-coupling reaction

Author affiliations

Abstract

The remote C–O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions. The positionally selective esterification protocol afforded C–O coupling products in moderate to excellent yields. Most importantly, this method may provide a potential alternative to the existing ways to build functionalized 5-hydroxyquinoline derivatives, which are utilized as pivotal intermediates in the synthesis of drug candidates.

Graphical abstract: Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp2)–O cross-coupling reaction

Back to tab navigation

Supplementary files

Article information


Submitted
01 Nov 2016
Accepted
28 Nov 2016
First published
29 Nov 2016

Org. Biomol. Chem., 2017,15, 531-535
Article type
Communication

Selective remote esterification of 8-aminoquinoline amides via copper(II)-catalyzed C(sp2)–O cross-coupling reaction

C. Xia, K. Wang, J. Xu, C. Shen, D. Sun, H. Li, G. Wang and P. Zhang, Org. Biomol. Chem., 2017, 15, 531
DOI: 10.1039/C6OB02375D

Social activity

Search articles by author

Spotlight

Advertisements