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Issue 32, 2016

High-affinity host–guest chemistry of large-ring cyclodextrins

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Abstract

The host–guest chemistry of large-ring cyclodextrins (LRCDs) has been largely unexplored due to the lack of suitable guest molecules that bind with significant affinities to enable potential applications. Herein, we report their complexation with dodecaborate anions (B12X122−), a novel class of guest molecules. The binding constants of the inorganic guests (104–106 M−1) allow their classification as the first tight binders for LRCDs.

Graphical abstract: High-affinity host–guest chemistry of large-ring cyclodextrins

Article information


Submitted
27 May 2016
Accepted
20 Jul 2016
First published
20 Jul 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 7702-7706
Article type
Paper

High-affinity host–guest chemistry of large-ring cyclodextrins

K. I. Assaf, D. Gabel, W. Zimmermann and W. M. Nau, Org. Biomol. Chem., 2016, 14, 7702 DOI: 10.1039/C6OB01161F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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