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Issue 28, 2016
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Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

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Abstract

A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.

Graphical abstract: Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

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Publication details

The article was received on 04 Apr 2016, accepted on 14 Jun 2016 and first published on 16 Jun 2016


Article type: Paper
DOI: 10.1039/C6OB00706F
Org. Biomol. Chem., 2016,14, 6853-6856

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    Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

    M. D. Stephens, N. Yodsanit and C. Melander, Org. Biomol. Chem., 2016, 14, 6853
    DOI: 10.1039/C6OB00706F

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