Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 15, 2016
Previous Article Next Article

Fe-catalyzed synthesis of substituted N-aryl oxazolidines

Author affiliations

Abstract

A novel iron-catalyzed synthesis of substituted N-aryl oxazolidines was developed via C–N bond formation and methylenation. The reaction of aryl hydroxylamines with allyl alcohols, in the presence of formaldehyde or its equivalents, afforded variety of oxazolidine heterocycles in very good yields. This catalytic method is most effective for para-substituted aryl hydroxylamines and 3-methyl allyl alcohols. Furthermore, acid catalyzed demethylenation of oxazolidines allowed access to N-aryl amino alcohols in good yields.

Graphical abstract: Fe-catalyzed synthesis of substituted N-aryl oxazolidines

Back to tab navigation

Supplementary files

Article information


Submitted
22 Jan 2016
Accepted
16 Mar 2016
First published
16 Mar 2016

Org. Biomol. Chem., 2016,14, 3681-3685
Article type
Communication

Fe-catalyzed synthesis of substituted N-aryl oxazolidines

S. Murru, C. S. Lott, B. McGough, D. M. Bernard and R. S. Srivastava, Org. Biomol. Chem., 2016, 14, 3681
DOI: 10.1039/C6OB00185H

Social activity

Search articles by author

Spotlight

Advertisements