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Issue 1, 2016
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Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

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Abstract

In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.

Graphical abstract: Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

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Supplementary files

Article information


Submitted
29 Oct 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Org. Biomol. Chem., 2016,14, 59-64
Article type
Communication

Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

J. Fu, Z. Na, B. Peng, M. Uttamchandani and S. Q. Yao, Org. Biomol. Chem., 2016, 14, 59
DOI: 10.1039/C5OB02233A

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