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Issue 34, 2015
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Cu-mediated direct regioselective C-2 chlorination of indoles

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Abstract

Cu-mediated C-2 chlorination of indoles was accomplished with copper(II) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.

Graphical abstract: Cu-mediated direct regioselective C-2 chlorination of indoles

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Publication details

The article was received on 16 Jun 2015, accepted on 27 Jul 2015 and first published on 30 Jul 2015


Article type: Communication
DOI: 10.1039/C5OB01228G
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Citation: Org. Biomol. Chem., 2015,13, 9000-9004

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    Cu-mediated direct regioselective C-2 chlorination of indoles

    J. Zhao, X. Cheng, J. Le, W. Yang, F. Xue, X. Zhang and C. Jiang, Org. Biomol. Chem., 2015, 13, 9000
    DOI: 10.1039/C5OB01228G

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