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Issue 46, 2014
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Design strategies for bioorthogonal smart probes

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Abstract

Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or therapeutic agents upon reaction, allow for the visualization of biomolecules or targeted delivery even in the presence of excess unreacted probe. This review discusses the strategies used in the development of bioorthogonal smart probes and highlights the potential of these probes to further our understanding of biology.

Graphical abstract: Design strategies for bioorthogonal smart probes

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Article information


Submitted
30 Jul 2014
Accepted
15 Sep 2014
First published
15 Oct 2014

Org. Biomol. Chem., 2014,12, 9307-9320
Article type
Review Article

Design strategies for bioorthogonal smart probes

P. Shieh and C. R. Bertozzi, Org. Biomol. Chem., 2014, 12, 9307
DOI: 10.1039/C4OB01632G

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