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Issue 6, 2013
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A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

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Abstract

A highly efficient enantioselective Darzens reaction of aldehydes with diazoacetamides catalyzed by a (+)-pinanediol–Ti(OiPr)4 system has been developed. The cis-glycidic amides were obtained in high yields and with moderate to excellent enantioselectivity (up to 99%).

Graphical abstract: A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

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Publication details

The article was received on 09 Nov 2012, accepted on 19 Dec 2012 and first published on 20 Dec 2012


Article type: Communication
DOI: 10.1039/C2OB27179F
Org. Biomol. Chem., 2013,11, 900-904

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    A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

    G. Liu, D. Zhang, J. Li, G. Xu and J. Sun, Org. Biomol. Chem., 2013, 11, 900
    DOI: 10.1039/C2OB27179F

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