Issue 6, 2013
From the journal:

Organic & Biomolecular Chemistry

Enantioselective α-hydroxylation of β-ketoamides†

Claudia De Fusco,a   Sara Meninno,a   Consiglia Tedescoa  and  Alessandra Lattanzi*a  

* Corresponding authors

a Dipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, Fisciano, Italy
E-mail: lattanzi@unisa.it
Fax: +39-089-969603

Abstract

The first enantioselective α-hydroxylation reaction of α-substituted β-ketoamides has been developed by using the commercially available hydroquinine/TBHP system. The tertiary alcohols are obtained in good to high yield and up to 83% ee, which can be improved by a single crystallization.

Graphical abstract: Enantioselective α-hydroxylation of β-ketoamides

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Article information

DOI
https://doi.org/10.1039/C2OB27283K
Article type
Communication
Submitted
25 Nov 2012
Accepted
17 Dec 2012
First published
17 Dec 2012

Org. Biomol. Chem., 2013,11, 896-899

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Enantioselective α-hydroxylation of β-ketoamides

C. De Fusco, S. Meninno, C. Tedesco and A. Lattanzi, Org. Biomol. Chem., 2013, 11, 896 DOI: 10.1039/C2OB27283K

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