Issue 5, 2013

Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Abstract

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

Graphical abstract: Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Supplementary files

Article information

Article type
Paper
Submitted
10 Sep 2012
Accepted
13 Nov 2012
First published
13 Nov 2012

Org. Biomol. Chem., 2013,11, 814-820

Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

J. Hu, Q. Yang, J. Xu, C. Huang, B. Fan, J. Wang, C. Lin, Z. Bian and A. S. C. Chan, Org. Biomol. Chem., 2013, 11, 814 DOI: 10.1039/C2OB26775F

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