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Issue 5, 2013
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Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

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Abstract

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

Graphical abstract: Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

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Publication details

The article was received on 10 Sep 2012, accepted on 13 Nov 2012 and first published on 13 Nov 2012


Article type: Paper
DOI: 10.1039/C2OB26775F
Org. Biomol. Chem., 2013,11, 814-820

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    Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

    J. Hu, Q. Yang, J. Xu, C. Huang, B. Fan, J. Wang, C. Lin, Z. Bian and A. S. C. Chan, Org. Biomol. Chem., 2013, 11, 814
    DOI: 10.1039/C2OB26775F

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