Issue 19, 2011

Practical and stereoselective synthesis of β-amino sulfones from alkyl phenyl sulfones and N-(tert-butylsulfinyl) aldimines

Abstract

A practical and straightforward approach for the highly stereoselective synthesis of β-amino sulfones was developed. With lithium bis(trimethylsilyl)amide as the base, the corresponding sulfone-stabilized carbanion derived from alkylphenyl sulfone can be transferred to N-(tert-butylsulfinyl) aldimines in excellent yields and with high diastereoselectivity.

Graphical abstract: Practical and stereoselective synthesis of β-amino sulfones from alkyl phenyl sulfones and N-(tert-butylsulfinyl) aldimines

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2011
Accepted
01 Aug 2011
First published
02 Aug 2011

Org. Biomol. Chem., 2011,9, 6502-6505

Practical and stereoselective synthesis of β-amino sulfones from alkyl phenyl sulfones and N-(tert-butylsulfinyl) aldimines

H. Zhang, Y. Li, W. Xu, W. Zheng, P. Zhou and Z. Sun, Org. Biomol. Chem., 2011, 9, 6502 DOI: 10.1039/C1OB05992K

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