Supramolecular helical porphyrin arrays using DNA as a scaffold

Abstract

A diphenyl porphyrin substituted nucleotide was incorporated site specifically into DNA, leading to helical stacked porphyrin arrays in the major groove of the duplexes. The porphyrins show an electronic interaction which is significantly enhanced compared to the analogous tetraphenyl porphyrin (TPP) as shown in the large exciton coupling of the porphyrin B-band absorbance. Analogous to the TPP–DNA, an induced helical secondary structure is observed in the single strand porphyrin–DNA. The modified DNA can be hybridised to an immobilised complementary strand leading to fluorescent beads.