Issue 21, 2008
From the journal:

Organic & Biomolecular Chemistry

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions†

Jean-Paul Desaulniers,‡a   Yu-Cheng Chang,§a   Raviprasad Aduri,a   Sanjaya C. Abeysirigunawardena,a   John SantaLucia, Jr.a  and  Christine S. Chow*a  

* Corresponding authors

a Department of Chemistry, Wayne State University, Detroit, Michigan, USA
E-mail: csc@chem.wayne.edu
Fax: 313-577-8822
Tel: 313-577-2594

Abstract

The 1H NMR spectra of RNAs representing E. coli23S rRNA helix 69 with [1,3-15N]pseudouridine modification at specific sites reveal unique roles for pseudouridine in stabilizing base-stacking interactions in the hairpin loop region.

Graphical abstract: Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

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Article information

DOI
https://doi.org/10.1039/B812731J
Article type
Communication
Submitted
24 Jul 2008
Accepted
01 Sep 2008
First published
19 Sep 2008

Org. Biomol. Chem., 2008,6, 3892-3895

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Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

J. Desaulniers, Y. Chang, R. Aduri, S. C. Abeysirigunawardena, J. SantaLucia, Jr. and C. S. Chow, Org. Biomol. Chem., 2008, 6, 3892 DOI: 10.1039/B812731J

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