Issue 8, 2006
From the journal:

Organic & Biomolecular Chemistry

Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

Benjamin C. Gorskea  and  Helen E. Blackwell*a  

* Corresponding authors

a Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI, USA
E-mail: blackwell@chem.wisc.edu
Fax: +1 608 265 4534
Tel: +1 608 262 1503

Abstract

Pathogenesis in Staphylococcus aureus is dependent on local cell density and is regulated in part by small macrocyclic peptides. Natural and artificial peptide inhibitors of this quorum sensing response have been synthesized and evaluated in structure–activity relationship studies. These investigations have illuminated the quorum sensing mechanism and set the stage for the design of biostable, peptidomimetic inhibitors that could be developed ultimately as therapeutics.

Graphical abstract: Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

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Article information

DOI
https://doi.org/10.1039/B517681F
Article type
Emerging Area
Submitted
13 Dec 2005
Accepted
20 Feb 2006
First published
16 Mar 2006

Org. Biomol. Chem., 2006,4, 1441-1445

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Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

B. C. Gorske and H. E. Blackwell, Org. Biomol. Chem., 2006, 4, 1441 DOI: 10.1039/B517681F

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