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Issue 12, 2004
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Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis

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Abstract

Bromopolystyrene beads with diameters of up to 600 µm have been derivatized completely, via bromine–magnesium exchange and interception with electrophiles, to yield high quality solid-supported reagents, scavengers and solid supports for use in diversity-oriented synthesis.

Graphical abstract: Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis

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Publication details

The article was received on 19 Feb 2004, accepted on 30 Apr 2004 and first published on 13 May 2004


Article type: Communication
DOI: 10.1039/B406488G
Org. Biomol. Chem., 2004,2, 1679-1681

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    Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis

    G. L. Thomas, M. Ladlow and D. R. Spring, Org. Biomol. Chem., 2004, 2, 1679
    DOI: 10.1039/B406488G

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