Issue 12, 2004
From the journal:

Organic & Biomolecular Chemistry

Synthesis and application in asymmetric C–C bond formation of solution phase ligand libraries of monodentate phosphoramidites†

Ate Duursma,a   Laurent Lefort,b   Jeroen A. F. Boogers,b   André H. M. de Vries,b   Johannes G. de Vries,*ab   Adriaan J. Minnaard*a  and  Ben L. Feringa*a  

* Corresponding authors

a Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
E-mail: b.l.feringa@chem.rug.nl
Fax: (+31) 50-3634296
Tel: (+31) 50-3634278

b DSM Pharma Chemicals-Advanced Synthesis, Catalysis and Development, P.O. Box 18, 6160 MD Geleen, The Netherlands

Abstract

A library of 96 unique monodentate phosphoramidite ligands has been synthesized in solution and used in the asymmetric conjugate addition of potassium vinyltrifluoroborate to enones resulting in up to 88% ee.

Graphical abstract: Synthesis and application in asymmetric C–C bond formation of solution phase ligand libraries of monodentate phosphoramidites

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Article information

DOI
https://doi.org/10.1039/B404996A
Article type
Communication
Submitted
02 Apr 2004
Accepted
12 May 2004
First published
25 May 2004

Org. Biomol. Chem., 2004,2, 1682-1684

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Synthesis and application in asymmetric C–C bond formation of solution phase ligand libraries of monodentate phosphoramidites

A. Duursma, L. Lefort, J. A. F. Boogers, A. H. M. de Vries, J. G. de Vries, A. J. Minnaard and B. L. Feringa, Org. Biomol. Chem., 2004, 2, 1682 DOI: 10.1039/B404996A

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