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Issue 39, 2016

Probing cell internalisation mechanics with polymer capsules

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Abstract

We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(methacrylic acid) (PMA) capsules with tuneable mechanical properties were fabricated through layer-by-layer assembly. The Pin was quantified by correlating the cell-induced deformation with the ex situ osmotically induced deformation of the polymer capsules. Ultimately, we found that human monocyte-derived macrophage THP-1 cells exerted up to approximately 360 kPa on the capsules during internalisation.

Graphical abstract: Probing cell internalisation mechanics with polymer capsules

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Article information


Submitted
22 Aug 2016
Accepted
11 Sep 2016
First published
22 Sep 2016

This article is Open Access

Nanoscale, 2016,8, 17096-17101
Article type
Communication

Probing cell internalisation mechanics with polymer capsules

X. Chen, J. Cui, Y. Ping, T. Suma, F. Cavalieri, Q. A. Besford, G. Chen, J. A. Braunger and F. Caruso, Nanoscale, 2016, 8, 17096 DOI: 10.1039/C6NR06657G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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