Issue 2, 2015

Nanotextured stainless steel for improved corrosion resistance and biological response in coronary stenting

Abstract

Nanosurface engineering of metallic substrates for improved cellular response is a persistent theme in biomaterials research. The need to improve the long term prognosis of commercially available stents has led us to adopt a ‘polymer-free’ approach which is cost effective and industrially scalable. In this study, 316L stainless steel substrates were surface modified by hydrothermal treatment in alkaline pH, with and without the addition of a chromium precursor, to generate a well adherent uniform nanotopography. The modified surfaces showed improved hemocompatibility and augmented endothelialization, while hindering the proliferation of smooth muscle cells. Moreover, they also exhibited superior material properties like corrosion resistance, surface integrity and reduced metal ion leaching. The combination of improved corrosion resistance and selective vascular cell viability provided by nanomodification can be successfully utilized to offer a cell-friendly solution to the inherent limitations pertinent to bare metallic stents.

Graphical abstract: Nanotextured stainless steel for improved corrosion resistance and biological response in coronary stenting

Article information

Article type
Paper
Submitted
29 Aug 2014
Accepted
17 Nov 2014
First published
20 Nov 2014

Nanoscale, 2015,7, 832-841

Author version available

Nanotextured stainless steel for improved corrosion resistance and biological response in coronary stenting

C. C. Mohan, A. Prabhath, A. M. Cherian, S. Vadukumpully, S. V. Nair, K. Chennazhi and D. Menon, Nanoscale, 2015, 7, 832 DOI: 10.1039/C4NR05015K

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