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Issue 24, 2014
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Enzymatic ‘stripping’ and degradation of PEGylated carbon nanotubes

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Abstract

Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of ‘stripping’ (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising – and degradable – nanomedicine vector.

Graphical abstract: Enzymatic ‘stripping’ and degradation of PEGylated carbon nanotubes

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Publication details

The article was received on 27 Jun 2014, accepted on 19 Oct 2014 and first published on 30 Oct 2014


Article type: Communication
DOI: 10.1039/C4NR03604B
Nanoscale, 2014,6, 14686-14690

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    Enzymatic ‘stripping’ and degradation of PEGylated carbon nanotubes

    K. Bhattacharya, C. Sacchetti, R. El-Sayed, A. Fornara, G. P. Kotchey, J. A. Gaugler, A. Star, M. Bottini and B. Fadeel, Nanoscale, 2014, 6, 14686
    DOI: 10.1039/C4NR03604B

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