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Issue 20, 2014

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

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Abstract

Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.

Graphical abstract: Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Article information


Submitted
22 Jun 2014
Accepted
31 Jul 2014
First published
05 Aug 2014

This article is Open Access

Nanoscale, 2014,6, 11553-11573
Article type
Feature Article
Author version available

Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

A. Hervault and N. T. K. Thanh, Nanoscale, 2014, 6, 11553 DOI: 10.1039/C4NR03482A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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