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Issue 8, 2014
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Biosynthesis of natural products containing β-amino acids

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Abstract

Covering: up to January, 2014

We focus here on β-amino acids as components of complex natural products because the presence of β-amino acids produces structural diversity in natural products and provides characteristic architectures beyond those of ordinary α-L-amino acids, thus generating significant and unique biological functions in nature. In this review, we first survey the known bioactive β-amino acid-containing natural products including nonribosomal peptides, macrolactam polyketides, and nucleoside–β-amino acid hybrids. Next, the biosynthetic enzymes that form β-amino acids from α-amino acids and the de novo synthesis of β-amino acids are summarized. Then, the mechanisms of β-amino acid incorporation into natural products are reviewed. Because it is anticipated that the rational swapping of the β-amino acid moieties with various side chains and stereochemistries by biosynthetic engineering should lead to the creation of novel architectures and bioactive compounds, the accumulation of knowledge regarding β-amino acid-containing natural product biosynthetic machinery could have a significant impact in this field. In addition, genome mining of characteristic β-amino acid biosynthetic genes and unique β-amino acid incorporation machinery could lead to the discovery of new β-amino acid-containing natural products.

Graphical abstract: Biosynthesis of natural products containing β-amino acids

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Publication details

The article was received on 20 Jan 2014 and first published on 13 Jun 2014


Article type: Review Article
DOI: 10.1039/C4NP00007B
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Nat. Prod. Rep., 2014,31, 1056-1073
  • Open access: Creative Commons BY-NC license
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    Biosynthesis of natural products containing β-amino acids

    F. Kudo, A. Miyanaga and T. Eguchi, Nat. Prod. Rep., 2014, 31, 1056
    DOI: 10.1039/C4NP00007B

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