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Issue 11, 2011
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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

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Abstract

Covering: up to March 2011

Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular frameworks, similar biosynthesis pathways and, most importantly, identical modes-of-action, being irreversible proteasome inhibition. With this report, we aim to review their chemical biology, describing their common, but also differential characteristics.

Graphical abstract: The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

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Article information


Submitted
08 Jun 2011
First published
09 Sep 2011

Nat. Prod. Rep., 2011,28, 1854-1867
Article type
Review Article

The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)

D. Krahn, C. Ottmann and M. Kaiser, Nat. Prod. Rep., 2011, 28, 1854
DOI: 10.1039/C1NP00048A

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