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Issue 11, 2011
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Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

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Abstract

Covering: up to the end of May 2011

Glyco(randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.

Graphical abstract: Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

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Publication details

The article was received on 02 Jun 2011 and first published on 08 Sep 2011


Article type: Review Article
DOI: 10.1039/C1NP00045D
Nat. Prod. Rep., 2011,28, 1811-1853

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    Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

    R. W. Gantt, P. Peltier-Pain and J. S. Thorson, Nat. Prod. Rep., 2011, 28, 1811
    DOI: 10.1039/C1NP00045D

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