Preparation and antibacterial behaviour of nanostructured Ag@SiO2–penicillin with silver nanoplates

Mahdieh Malekzadeh; King Lun Yeung; Mohammad Halali; Qing Chang

doi:10.1039/C9NJ03727F

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Preparation and antibacterial behaviour of nanostructured Ag@SiO₂–penicillin with silver nanoplates†

Mahdieh Malekzadeh,

*^ab King Lun Yeung,^bc Mohammad Halali^a and Qing Chang^b

Author affiliations

* Corresponding authors

^a Department of Materials Science and Engineering, Sharif University of Technology (SUT), Azadi Street, Tehran, Iran
E-mail: mah_malekzadeh@yahoo.com

^b Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China

^c Division of Environment and Sustainability, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China

Abstract

In this study, we investigated the antibacterial properties of nanostructured Ag@SiO₂–penicillin synthesized from triangular silver nanoplates (Ag NPs) against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) bacteria. The Ag@SiO₂–penicillin nanoparticles contained approximately 33.2 wt% Ag as determined by ICP-OES. Grafting of about 2.8 wt% penicillin on Ag@SiO₂ remarkably enhanced the bactericidal properties against MSSA and MRSA bacteria and showed no cell-death inducing effects towards the A431 cell line.

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Article information

DOI: https://doi.org/10.1039/C9NJ03727F
Article type: Paper
Submitted: 17 Jul 2019
Accepted: 29 Sep 2019
First published: 30 Sep 2019

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New J. Chem., 2019,43, 16612-16620

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Preparation and antibacterial behaviour of nanostructured Ag@SiO₂–penicillin with silver nanoplates

M. Malekzadeh, K. L. Yeung, M. Halali and Q. Chang, New J. Chem., 2019, 43, 16612 DOI: 10.1039/C9NJ03727F

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