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Issue 10, 2016
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Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

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Abstract

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.

Graphical abstract: Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

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Supplementary files

Article information


Submitted
30 Jun 2016
Accepted
26 Jul 2016
First published
27 Jul 2016

Med. Chem. Commun., 2016,7, 1952-1956
Article type
Research Article

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

M. D. Stephens, N. Yodsanit and C. Melander, Med. Chem. Commun., 2016, 7, 1952
DOI: 10.1039/C6MD00365F

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